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My MIL had a problem with Aricept and a dopamine blocker. Drug names here and in the US are different so I don't know what the medication she took corresponded to.
It was prescribed, with Aricept, by the first doctor who saw her, the dementia specialist, as she was quite paranoid and aggressive at that time. Her scan showed a deficit in the left frontal lobe as well as the hippocampus, the doctor told us she has 'mixed dementia'.
The Aricept began to work wonders for her, but suddenly she went into an almost comatose state, not a true coma but pretty unresponsive. She couldn't eat, sit up, needed pull-ups for the first time. It turned out that the combination of the two medications gave her a severe electrolyte imbalance. She came out of it in a couple of days with saline IVs. She was taken off the dopamine blocker immediately and since has done very well with Aricept alone. She still has suspicions about people and things she can't find, but it isn't worth the risk to give her another medication.
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